Recipient: University Hospital Jena
Funding: GO-Bio initial conceptual phase 4 (01/10/2023 to 30/09/2024, EUR 119,996.29)

Project description:

Innovative methods that can be used to detect and quantify single-cell changes (e.g., in cancer cells) offer the possibility of taking the associated research and diagnostics to a new level. The aim of the project is to establish the newly developed biophotonic method of the so-called UV Laser Crosslinking Flow Cytometry (Laser-Flow) as a broadly applicable technology for research and diagnostics, which is based on the interaction of light with organic material. Laser-Flow can quickly and highly specifically quantify specific DNA-bound proteins in the single cells of cell mixtures. As part of the exploratory phase the most promising fields of application in research and diagnostics are to be evaluated. These are to be evaluated in terms of feasibility, potential benefits and market, and the necessary experiments and analyses are to be prepared for the feasibility phase. The technical aim of the thesis is to evaluate further improvements of the technology and particularly to investigate the possibilities for the development of a user-friendly and cost-effective device for sole use or integration into existing diagnostic pipelines. Intellectual property rights and potential markets will additionally be examined.