Recipient: Karlsruhe Institute of Technology
Funding: GO-Bio initial conceptual phase 4 (01/10/2023 to 30/09/2024, EUR 100,000.00)

Project description:

In the field of drug development there are still no suitable test systems to characterise the effect of drug candidates on in-vitro cellular respiration. Increasingly more complex cell culture models based on organoids, for example, are being developed, but as yet there are no suitable methods for determining oxygen in the microenvironment of these organoids. The 3D physioxia assays to be developed are based on optical oxygen measurement in so-called sensor arrays. These arrays consist of oxygen-sensitive microvessels for cultivating and measuring the oxygen consumption of organoids. For the first time this makes it possible to measure oxygen under physiological conditions in the microenvironment of organoids. The assays can lead to obtaining reliable data at an early stage of drug development and to excluding potentially harmful drug candidates from further development. The GO-Bio initial exploratory phase will make it possible to identify the most promising market segments and prepare the application for the subsequent feasibility phase.